I don't personally have a problem with it, but in most of the Last Words strips I wrote, the characters tended to treat the "camera" as if it were another one of them and the viewer wasn't there but rather just seeing it through that person's eyes. So while they often addressed the viewer, they didn't usually draw attention to the fact that they live in a comic. I never consciously made a choice to avoid obviously saying "it's a comic!", but I kind of did avoid it anyway.
The few comics I did that directly addressed the 4th wall issue usually played on the format of webcomics and how we have to scroll down the page, like this one
Most of all, I think it's just a matter of writing. Any subject can be crappy if it's written poorly. I think as a result of the nature of the 4th wall, it becomes more obvious when it's poorly written than say if you butchered a joke about chickens and asphalt.