For some of you, the answer to that question is a definite "yes", but for others a little bit more detail might not hurt.
So here's my question, why not go vector?
On the open clip art library [openclipart.org] I found a set of Pacman ghosts that were liscenced as being Public Domain, meaning that they're legally free to use, so that you can use the images in any way you feel, without ever fearing that the original creator might take legal action on you. (although I do recommend giving credit to the guy, just to thank him.)
All you need to use them is a vector application that supports svg files. I recommend Inkscape [inkscape.org], though there are many other free vector editors out there. Adobe Illustrator is nice, if you want to do fancier things with them, but the blurs don't quite import from the SVG format well (for CS2 at least).
Anyways, here's a link to the pack. Right click and chose "save link/target as..." to save the SVG files for each.:
http://clipart.nicubunu.ro/?gallery=pacman [clipart.nicubunu.ro]
The creator also did a screencast showing how he created the images.
http://clipart.nicubunu.ro/?gallery=pacman [clipart.nicubunu.ro]
I'm really not a sprite/clipart comic guy, but I'll see if I can show some uses for them.
-------------------EDIT------------------------
Well, I wasn't feeling very creative.
Notice how the ghosts were resized to be much larger than they originally were, and yet there is no pixelization. (you have to "right click> view image" first) That's the beauty of vector creations.




