Well, I have an almost completely new cast in issue 3 and tons of work to procrastinate, so here goes...
Bulletproof: Seed of Evil
Casper Van Dien as Vector
Still clearly my choice for this guy. I need someone as square-jawed as possible who isn't above playing a total douchebag here, so Van Dien it is.
Kristen Bell as Shyft
She usually plays more likeable characters, but that's exactly why I'd cast her as Shyft. You think she's cute and you want to flirt with her, and then she puts a bullet between your eyes.
Steve Bacic as Hornet
He played the asskicker/boyscout in season 4 of Andromeda, and, well, he's beefy.
Neil Patrick Harris as Firewing
I can't really think of anyone else except Carrot Top, and that's not really an option. And Harris actually did Peter Parker's voice before, so he's got... y'know... cred.
Michael Clarke Duncan as Ravage
Kinda the obvious choice here, but we need that booming black man's voice for Ravage. He'd have to be a CGI character anyway, actually, so it doesn't matter that Duncan's almost big enough for the part, it's really just the voice.
Kelly Hu as Shadow
Short of going the blatantly obvious route and casting Lucy Liu, seriously... who else? She kicked all kinds of ass in X2, she's Asian, and she's hot. Sold.
Alec Baldwin as Alexander Quinn
You know that overbearing asshole he played in Glengarry Glen Ross? Bingo. I know he's way too famous for a part like this, but Alec Baldwin IS Alexander Quinn.
Ali Larter as Fang
She's actually not quite curvy enough, but we need a cool blonde here who's strikingly beautiful and can play a psycho killer. You've seen Heroes, right? There you go.
Thora Birch as Darkspot
She can act, she's got the look, and well damn, she's practically wearing the outfit in this pic.
Roselyn Sanchez as Tarantula
Hot latina + supermodel body = Tarantula.
Eric Roberts as the voice of Widowmaker
Widowmaker's obviously an all-CGI character, so looks don't matter, and Eric Roberts can do slightly campy one-liners with the best of 'em.
Matthew Gray Gubler as Mouse
This was a tough one. "Slightly creepy but not entirely unlikeable" is what we're looking for here, and Gubler's character in Criminal Minds is pretty much that.
Evan Handler as Jackborg
Not skinny enough, really, but he's short and bald and when he played that lawyer on 24, he was the creepy guy who you wanted to punch in the face within 10 seconds of meeting him, and that's how people are supposed to feel about Jackborg.
Myla Leigh Chenoa as Nyx
I don't know if she can act, but she looks almost exactly right. Plus, come on, you want to see her in that outfit. Heh.