I use Photoshop CS for sketching, inking, and coloring (once in a blue moon I will use Corel Painter if I'm trying to get an effect that I can't easily reproduce in Photoshop), and then I pop pages open in Illustrator to add sound effects and text bubbles. I find working with text to be much easier in Illustrator than in Photoshop, mostly because I can just drag to resize instead of having to punch in numbers and guess. And getting effects for text for sound effects is also much easier for me in Illustrator.

I've been using Photoshop a lot lately since I want to become proficient with the program. It's industry standard and I feel that it would be worth it to my career to get very good at it.

My first digital love will always be Open Canvas though. I just love what the watercolor tool does to my work.