What first comes to mind are the DirecTV football ads with Dennis Leary:

"What, there was a football game on, and instead of staying at home, you were spending time with your family?" What are you, queer or something?"

The Twix "Get The Girl" ads just plain creep me out:

"Twix will totally help you lie to a girl to get in her pants! The Mars Candy Corporation wants you to get laid in the shade, buddy boy!"

It's like the world's skeeviest condom commercial.