I've been planning for a while, on the sage advice of Ozone Ocean, to make lower file sized pages for my comic and replace all my pages with the smaller ones so that non broadband people can enjoy reading, and it loads a bit faster for Broadbanders too.
I have one concern though. If I edit pages, uploading a new file in their place, it won't delete all my comments and stuff, will it? I don't think it will, but I want to make sure before I start making jpgs of 80+ pages and uploading them.
However with the updating issues lately, you should only try to re-upload a couple of them first to see if that function works right now, or to see if there's a delay between when you upload it and when the changes show up.